Day 1: Arrival and a walk along the São Francisco riverside
Start your visit to Petrolina with a relaxed walk along the riverside promenade, one of the city's postcard spots. The São Francisco River, one of Brazil's most important waterways, is the perfect backdrop for observing local daily life and catching the sunset. After checking in, if you're staying at Maison Hotel Petrolina, make the most of its central location to explore the nearby commercial streets before dinner, capping off the day with a regional dish paired with freshwater fish.

Day 2: Wineries and irrigated farming in the São Francisco Valley
Set aside the second day to discover one of the region's most interesting quirks: wine production in a semi-arid tropical climate. The valley's irrigated vineyards yield grapes almost year-round, a rarity worldwide, and several estates offer guided tours with tastings. Also take the chance to visit mango plantations, another of the region's major agricultural products, and see how irrigation has turned this part of the sertão into an important fruit-producing hub.
Day 3: Crossing to Juazeiro and riverside life
On the third day, cross one of the bridges over the São Francisco River to visit Juazeiro, in Bahia, Petrolina's sister city, with which it shares a closely intertwined urban and cultural dynamic. The crossing between the two cities is an interesting experience in its own right, offering different vantage points on life along the river. Return to Petrolina in the late afternoon for one last meal and, if possible, a boat trip to see the city from the water.

Where to stay during the trip
For a central and practical base across these three days, Novo Sol Hotel is a good option, as is Hotel de Trânsto de oficiais e sargentos do Exército, both well positioned for the daily movements of this itinerary.
Tips for getting the most out of the itinerary
To make the most of these three days, book winery visits in advance, since some estates only operate by prior reservation. Pack light clothing and sunscreen given the region's warm climate, and bring a reusable water bottle for outdoor excursions. If time allows, it is also worth setting aside an extra morning to explore the riverside at a more relaxed pace or visit a local market before moving on.
This three-day itinerary shows how Petrolina blends nature, agriculture and riverside culture in a way that's unique in Brazil's Northeast. Arrange your excursions ahead of time, especially the winery visits, and make the most of this city on the banks of the São Francisco.