Hotel São José is on Avenida Desembargador Osvaldo Sento Sé, in the town of Sento Sé, in the Bahian sertão region, by the Sobradinho reservoir. The reservoir, one of the largest in the world by flooded area, has profoundly reshaped the local economy and geography since its creation.

Sento Sé maintains a strong connection to the São Francisco river, historically known as the river of national integration, and the region combines the semi-arid caatinga landscape with the constant presence of the reservoir's vast body of water.