Hotel Reis is on the BR-407 highway, in Afrânio, a municipality in the sertão of Pernambuco, close to the São Francisco river. The region is characterised by caatinga vegetation and the semi-arid climate typical of the northeastern interior.
Afrânio lies along the BR-407, a major road crossing the Pernambuco sertão, linking the region to the city of Petrolina and the irrigated fruit-farming hub of the São Francisco Valley.