Hotel Puerta de Bilbao is located near Paseo Rafael Moreno "Pitxitxi" in Bilbao, the economic capital of the Basque Country. Over recent decades the city has transformed from an industrial centre into a cultural destination, symbolised by the Guggenheim Museum on the banks of the Nervión estuary.

The old town, the Casco Viejo, with its original seven streets, contrasts with the contemporary architecture along the riverfront. Basque cuisine, with its pintxos, is another of the city's draws.