Hotel Fazenda Alzira is in Manacapuru, in the state of Amazonas, on the banks of the Manacapuru river, near its confluence with the Solimões river. The town is about 68 kilometres from Manaus, connected by road and also by river.
Manacapuru is known for its annual agricultural fair, one of the largest in the interior of Amazonas, and for an economy tied to farming, fishing and cassava flour production, reflecting the riverside way of life typical of the Amazon region.